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Tokyo University of Pharmacy and Life Sciences, School of Life Sciences 

Laboratory of
 Bioorganic Chemistry

Ito Research Group

 

Announcement

Member

Staff

Professor: Hisanaka Ito, Ph.D.                                  itohisa@toyaku.ac.jp

Associate Professor: Hideki Abe, Ph.D.                   
abehidek@toyaku.ac.jp

Assistant professor: Toyoharu Kobayashi, Ph.D.     tkoba@toyaku.ac.jp

Graduate Student

D2: Ayumu Shinobe
 
M2: Motonobu Kuwayama, Takeru Shirasaka, Eri Nakagawa, Yuri Horii, Sayo Yamashita, Yuka Yomogita

M1: Takehiro Ishioka, Satoko Itaya, Ai Ushie, Kasumi Tokumoto, Yuki Yoshikawa, Takumi Wagatsuma

Under Graduate Student

Kousuke Emori, Momoyo Sakakibara, Ryuta Takahashi, Yuka Nagashima, Sakiko Nogami, Tatsuya Nogo
Rumi Mito, Naohiro Miyagawa, Yuta Miyazaki, Keisuke Morodome, Toshihiro Yoshie 

 

Research
 


We have been studying the following subjects regarding organic chemistry;

1) Development of efficient synthetic route to complex natural products and biologically active compounds.

2) Development of novel and useful synthetic methods  for natural product synthesis.




3) 
Development of functional fluorescence molecules.

   i) Novel ratiometric fluorescent molecule for zinc (II) ion





 
Publication

1. Hideki Abe, Akira Tezuka, Toyoharu Kobayashi, Hisanaka Ito, Synthesis of Oxygen-Bridged Decahydroazulene Derivatives: Simplified Analogues of Biologically Active Natural Products, 
Heterocycles, accepted.

2. Toyoharu Kobayashi, Hidenori Shiroi, Hideki Abe, and Hisanaka Ito, Synthetic Study of Presilphiperfolan-8-ol: Construction of the Tricyclo[5.3.1.04,11]undecane Framework Utilizing Intramolecular Aldol Condensation and McMurry Coupling, 
Chem. Lett. 201342, 975-976.

3. Hideki Abe, Akimi Sato, Toyoharu Kobayashi, and Hisanaka Ito, Concise Total Synthesis of Spirocurcasone, 
Org. Lett. 201315, 1298-1301.

4. Hideki Abe, Naoki Fukazawa, Toyoharu Kobayashi, and Hisanaka Ito, Indium Chloride mediated Chlorolactonization: Construction of Chlorinated Lactone Fragments, 
Tetrahedron 201369, 2519-2523.

5. Hideki Abe, Akimi Sato, Shin-ichi Tokishita, Toshihiro Ohta, and Hisanaka Ito, Synthesis of Fluorescence Pyriproxyfen Analogues as Juvenile Hormone Agonist, 
Heterocycles 201183, 1649-1658.

6. Yohei Ueda, Hideki Abe, Kazuo Iguchi, and Hisanaka Ito, Synthetic Study of Yonarolide: Stereoselective Construction of the Tricyclic Core, 
Tetrahedron Lett. 201152, 3379-3381.

7. Hisanaka Ito, Mai Matsuoka, Yohei Ueda, Madoka Takuma, Yoshihisa Kudo, and Kazuo Iguchi, Quinolinecarboxylic Acid Based Fluorescent Molecules: Ratiometric Response to Zn2+Tetrahedron 2009, 65, 4235-4238.

8. Hisanaka Ito, Takaya Inoue, and Kazuo Iguchi, Toward the Synthesis of Didemnaketal B: A Convergent Synthesis of the C9-C28 Subunit, Org. Lett. 2008, 10, 3873-3876.

9. Hisanaka Ito, Shunta Takeguchi, Takahiro Kawagishi, and Kazuo Iguchi, Total Synthesis of (±)-Clavubicyclone, Org. Lett. 2006, 8, 4883-4885. 

10. Hisanaka Ito, Mineki Hasegawa, Yosuke Takenaka, Tatsuya Kobayashi, and Kazuo Iguchi, Enantioselective Total Synthesis of (+)-Tricycloclavulone, J. Am. Chem. Soc. 2004126, 4520-4521.